MED8 and hepatocellular carcinoma: Mediator complex subunit 8 (MED8) correlated with poorer overall survival and advanced clinical stage and showed higher expression in metastatic than primary tumors in clear cell RCC (Syring et al., 2016).Phosphatidylinositol glycan anchor biosynthesis class U (PIGU) may promote HCC progression by activating the NF-κB pathway (Wei et al., 2020) and could be an oncogene in HCC (Cao et al., 2019).