Particularly, the variant of rs866882393, which eliminates the PAX5-binding motif in the promoter region of WFS1, was recurrently detected in three ADHD children, and it has been reported that the expression of WFS1 is closely correlated with neuronal differentiation (Tekko et al., 2014; Li et al., 2020). This evidence concerns the gene WFS1 and attention deficit-hyperactivity disorder.