IL1RN and idiopathic pulmonary fibrosis: Moreover, bronchoalveolar lavage fluid cells obtained from IPF patients during the onset of the disease produced higher levels of IL-1RA, CCL18, and other M2-related chemokines than cells obtained from the same patients outside the onset of the disease, and the higher the content of CCL18, the higher the seizure (Schupp et al., 1932).