Moreover, bronchoalveolar lavage fluid cells obtained from IPF patients during the onset of the disease produced higher levels of IL-1RA, CCL18, and other M2-related chemokines than cells obtained from the same patients outside the onset of the disease, and the higher the content of CCL18, the higher the seizure (Schupp et al., 1932). The gene discussed is IL1R1; the disease is idiopathic interstitial pneumonia.