METTL16 and central nervous system cancer: Subsequently, the differential analysis showed that, between glioma and normal brain tissue, a variety of m6A-related genes were differentially expressed, including METTL14, METTL16, ZC3H13, YTHDC1, YTHDC2, YTHDF2 (Zhang et al., 2017; Dixit et al., 2021; Fang et al., 2021)etc.