INS and nicotine dependence: m6A gene-A is involved in the synaptic vesicle cycle, insulin secretion, nicotine addiction, and GABAergic synapse pathways (Figure 4E), while the gene set overexpressing signature gene-B mainly manifests as the relaxin signaling pathway, AGE-RAGE signaling pathway in diabetic complications, ECM-receptor interaction, and protein digestion and absorption pathways (Figure 4F).