KEGG pathway analysis revealed that numerous pathways were enriched in controls but not in sepsis, including GnRH signaling pathway, gastric acid secretion, cholinergic synapse, ErbB signaling pathway, thyroid hormone synthesis, growth hormone synthesis, secretion and action, calcium signaling pathway, GABAergic synapse, axon guidance, and serotonergic synapse (Figure 4D). Here, GNRH1 is linked to Sepsis.