RIGI and coinfection: Interestingly, treatment of RAW macrophage with cGAMP led to a massive upregulation (30.04 fold) of probable ATP-dependent RNA helicase DHX58 (also known as LGP2 or Laboratory of Genetics and Physiology 2), which is known to inhibit antiviral signaling through RIG-1.32 Could this be an adaptive mechanism whereby the immune system has evolved to limit the damage that would ensue during viral and bacterial co-infection?