The role of KCTD12 in immunity is unclear, but it has been shown to affect the proliferation of other cell types.50 Luo et al. demonstrated that the over expression of KCTD12 in human uveal melanoma OCM-1 cells inhibited proliferation.51 In another report, Li et al. showed that colorectal cancer cells stemness was regulated by KCTD12 via the ERK pathway.50 The gene discussed is MAPK1; the disease is colorectal cancer.