PML and acute promyelocytic leukemia: Our results indicated that c-GAMP caused the upregulation of Uba7 (also called ubiquitin-activating enzyme E1-like, UBE1L) by 21.09 fold.45 UBE1L mRNA has been shown to be induced after rectinoic acid treatment of acute promyelocytic leukemia (APL), leading to PML/RARα degradation and apoptosis in acute promyelocytic leukemia.