Li et al. (2017) found that pretreatment with the TSPO agonist etifoxine assisted to contain the size of ischemia, reduce symptoms of neurological impairment and reduced cytokine release in response to the MCAO. However, the research for TSPO in other cell types required further investigations to better define (Li et al., 2017). On the one hand, the interaction between 14,15-EET and TSPO in brain injury is not clear. In our study, we wondered if EETs could protect the cells via regulating TSPO expression in brain ischemia. This evidence concerns the gene TSPO and ischemia.