Studies also corroborated that PPAR-α played defensive roles in the progression of IBD and CAC mainly via the stimulation of antimicrobial peptides RegIIIb and RegIIIg (Zheng et al., 2008; Killig et al., 2014) In interleukin 10 knockout (IL-10−/−) colitis mice, treatment with fenofibrate repressed interferon-gamma and IL-17 expression in isolated T cells. This evidence concerns the gene IL10 and colitis.