Similarly, GOT1 was significantly associated with various signaling pathways such as ECM–receptor interaction, carbon metabolism, human papillomavirus infection, AGE–RAGE signaling pathway in diabetic complications, focal adhesion, insulin resistance, lysosome, MAPK signaling pathway, peroxisome, and tight junction (Figure 4B; Supplementary Table S5). The gene discussed is INS; the disease is human papilloma virus infection.