Consistent with the results analyzed from the database, we examined the mRNA expression of the TMPRSS2 gene in human cancer cell lines or tumor tissues of LUAD and BRCA and confirmed that compared with normal cells or tissues, TMADSS2 is highly expressed in LUAD and lowly expressed in BRCA (Supplementary Figures S3A–C). The gene discussed is TMPRSS2; the disease is cancer.