In contrast, TMPRSS2 level was downregulated in the brain and CNS cancer, breast cancer, colorectal cancer, esophageal cancer, head and neck cancer, lung cancer, lymphoma, other cancer (mixed germ cell tumor, embryonal carcinoma, yolk sac tumor, testicular embryonal carcinoma, seminoma, testicular yolk sac tumor, uterine corpus leiomyoma, malignant fibrous histiocytoma, testicular seminoma), pancreatic cancer, and sarcoma (Figure 1A). Here, TMPRSS2 is linked to central nervous system cancer.