TMPRSS2 and breast cancer: However, the high expression of TMPRSS2 showed a poor prognosis in READ (OS HR = 2.2, 95% CI = 1 to 4.84, p = 0.043), breast cancer (OS HR = 1.59, p = 0.0047), and BRCA (OS HR = 1.5, p = 0.015) (Supplementary Figures 1C, H, I).