More specifically, the expression of AIM3, CASP3, CASP5, CASP6, CASP8, GPX4, GSDMB, GSDMD, NLRP2, NLRP7, PLCG1, and PYCARD was increased, while the expression of ELANE, IL6, NLRP1, and NLRP3 was decreased in bladder cancer compared with normal tissues. The gene discussed is CASP8; the disease is urinary bladder cancer.