Interestingly, when made by fibroblasts, it cleaves PAR1 (thrombin receptor), thereby inducing PAR1-dependent Ca2+ signals and enhancing the metastatic capacity of cancer cells (Wandel et al., 2000; Boire et al., 2005; Blackburn et al., 2009; Moro et al., 2014). Here, F2R is linked to cancer.