Fibronectin (FN) is also crucial for the metastatic spread of melanoma cells, it is regulated by ERK/MAPK signaling, modulates the process of epithelial-to-mesenchymal transition, regulates apoptosis, and supports cell invasion (Li B. et al., 2019); (Gaggioli et al., 2007). The gene discussed is FN1; the disease is melanoma.