By intravital imaging, Hirata et al. (2015) show that treatment of MAPK inhibitors activates peritumoral fibroblasts and induces enhanced FN whose binding to the integrin beta1/focal adhesion kinase/Src signaling provides an escape route for melanoma cells from treatment (Fedorenko et al., 2015; Hirata et al., 2015). Here, FN1 is linked to melanoma.