The results showed that older age (≥60 years, P = 0.001), men (P = 0.043), lower PLT (P = 0.046), higher BM blast percentage (>5%, P < 0.0001), higher-risk IPSS-R cytogenetic (P = 0.026), and higher levels of PLR (P = 0.031) and CRP (P = 0.029) were adverse situations and associated with a significantly worse OS in MDS patients. Here, CRP is linked to myelodysplastic syndrome.