In this study, we assessed the expression and prognostic value of MED8 in HCC patients and unveiled potential roles of MED8 underlying HCC tumor progression by generation of small interfering RNA (siRNA)-mediated MED8 knockdown HCC cell lines; we further explored whether a correlation existed between MED8 and HCC immune through bioinformatics analysis. This evidence concerns the gene MED8 and hepatocellular carcinoma.