It is also well-documented that increased inflammatory marker levels like IL-3455 greatly influence the pathophysiology of depressive and mood episodes in MDD and BD patients (88), IL-6 (89, 90), IL-10 (89), and CRP (90), neuronally derived exosome marker CD81 (88), also TSPO in brain regions like PFC, ACC, and insula (91). This evidence concerns the gene CD81 and major depressive disorder.