KL and Brain atrophy: These levels of Klotho were inversely associated with brain atrophy in AUD measured via computed tomography (CT), such that the levels were inversely related to several CT indices: bicaudate (minimum width of lateral ventricles/skull width at the same level), bifrontal (maximum width of frontal horns/skull width at the same level), Evans (maximum width of frontal horns/skull width at the level of the III ventricle) and a trend with cella index (width of the III ventricle/skull width at the same level).