Furthermore, the fluorescence quantification revealed an increased γH2AX staining level in GBM cells loaded with microdiscs in a dose-dependent manner; indeed Fig. 4 shows a higher H2AX staining for cells incubated with a concentration of 30 microdiscs per cell than cells incubated with 10 microdiscs per cells. The gene discussed is H2AX; the disease is glioblastoma.