OX40 and 4–1BB are costimulatory receptors of the TNF receptor family, linked to enhanced survival, cytotoxicity, and shown to counteract T cell exhaustion.15,16TNFRSF4/OX40 was highest in UPS, MFS (myxofibrosarcoma) and DDLS (dedifferentiated liposarcoma) compared to all other cancer types investigated. The gene discussed is TNFRSF4; the disease is myxofibrosarcoma.