Some biomarkers, for example, ESAT6 (Chiappini et al., 2012; Liu et al., 2017), IP-10 (Estevez et al., 2020), and CD161 (Yang et al., 2015), are secreted by either Mtb or the host and have been verified and validated for the detection of Mtb and TB diagnosis. This evidence concerns the gene CXCL10 and tuberculosis.