A differentially expressed gene (DEG) analysis of malignant cells (Figures S1A, B) revealed an enrichment of genes involved in cell-cycle-related pathways (e.g., E2F_targets, MYC_targets_V1, and G2M_checkpoint pathways) in T-ICC, whereas the genes upregulated in P-ICC mainly belonged to metabolism-related pathways (e.g., oxidative phosphorylation, fatty acid metabolism, xenobiotic metabolism). The gene discussed is MYC; the disease is intrahepatic cholangiocarcinoma.