Our results showed that the p-values of the six IRGs were less than 0.05; low expression of SOCS3, TCF7L2, and TSLP, and high expression of HMGB3 in BC was associated with poor prognosis; and low expression of NPR3 and ANO6 in BC was associated with good prognosis (Figure 3D). The gene discussed is HMGB3; the disease is breast cancer.