NFKB1 and neoplasm: Besides, another important functional mechanism of NF-κB in tumor cells is to promote cell survival by modulating the expression levels of anti-apoptotic genes such as BCL-2. Furthermore, more and more studies have indicated the inter-connections and compensatory pathways between NF-κB and HIF1-α system (18, 151, 152), linking innate immunity with hypoxic response.