Mechanistically, the expression level of JMJD2C protein was increased under the modulation of Wnt/β-catenin signaling pathway, and the protein product subsequently recruited β-catenin and co-located at the Jagged1 (JAG1) promoter for transactivation, thus enhancing the activation of Notch pathway and promoting the development of colorectal cancer (132). Here, JAG1 is linked to colorectal cancer.