Recent studies have suggested that H. pylori affected the invasion and metastasis of the gastric cancer by upregulating the expression of epithelial-mesenchymal transition (EMT)-related factors Snail 1, Slug and vimentin, partly relying on gastrin and matrix metalloproteinase 7 (MMP7), and enhancing the expression of Heparin-binding EGF-like growth factor (HB-EGF), thus promoting the EMT process in gastric cancer (81). This evidence concerns the gene HBEGF and gastric cancer.