Compared with TRPV3 low-expression groups, the ccRCC microenvironment with TRPV3-high expression contained a higher proportion of B cells memory, T cells CD8, T cells regulatory (Tregs), Mast cells activated, while T cells gamma delta, Monocytes, Macrophages M2, Mast cells resting infiltrated less (p<0.01; Figure 10B). Here, TRPV3 is linked to nonpapillary renal cell carcinoma.