On the other side, the upregulation of CD36 can alleviate microglia phagocytosis deficiency and spatial learning impairment of AD mice by intranasal administration of a kind of lentiviral vector encoding human nuclear factor erythroid 2-related factor 2 (LV-NRF2) which is a transcriptional activator to up-regulate CD36 expression (134). The gene discussed is CD36; the disease is Alzheimer disease.