have revealed that APOE, ABCA7, GPR141, PTK2B, SPI1 and ZYX etc. seemed to be upregulated, while MEF2C etc. remained downregulated in HAM from AD patients when compared with the control, in which, only APOE upregulation and SERPINF1 reduction achieved nominal genome-wide significance after correction for multiple testing (45). The gene discussed is APOE; the disease is Alzheimer disease.