Dapansutrile (OLT1177), an orally available small molecule inhibitor for NLRP3 inflammasome which can silence caspase-1 and IL-1β and has well tolerated and free side effects in humans, could rescue synaptic plasticity, suppress inimical microglia, and reduce the number of plaques in APP/PS1 mouse model for AD (59). This evidence concerns the gene CASP1 and Alzheimer disease.