Regarding involvement of RAGE in AD target therapy, there is now evidence that Aβ dependent impairments like dependent behavior and damaged dendritic spine morphology in the entorhinal cortex (EC) are rescued in transgenic mice with silenced RAGE of microglia via prohibiting kinases JNK and p38 mitogen-activated protein kinase (p38MAPK). The gene discussed is AGER; the disease is Alzheimer disease.