Specifically, M1 and M2 macrophages targeted other cells in the GALECTIN, GRN and SPP1 signaling pathway networks (Supplementary Figures 6C, D, G, H), and GBM cancer cells regulated other cells in the MK and PTN signaling pathway network (Supplementary Figures 6M, N; Supplementary Figures 6E, F). Here, GRN is linked to cancer.