SOX2 and cancer: For example, ALKBH5 promotes stemness of GSCs by sustaining FOXM1 expression (24, 25) and METTL3 (19), HNRNPA2B1 and HNRNPC (26) maintain stemness of GSCs by targeting SOX2. The product of the SOX2 gene is an oncogenic transcription factor in many cancers; accordingly, in the current research, we found significant positive correlations between SOX2 and YTHDC1, IGF2BP2, HNRNPC, ELAVL1, FMR1, KIAA1429, and ZC3H13 in GBM cancer cells (Figure 4D, E).