Increased irAE risk: mapped to One variant A allele in GABRP SNP rs11743438; One variant A allele in GABRP SNP rs11743435; one variant allele A in the DSC2 SNP JHU_20.57183980; one variant allele G in the BAZ2B SNP rs56328422; one variant allele T in the SEMA5A SNP rs3026321Post-treatment (3-week) increased expression of CD177GI (12.2 fold higher in ir-AE group than non-irAE group) and CEACAM1GI genes (118)Suppressed miR-146a gene (by SNP s2910164) (119)Reduced irAE risk: mapped to RGMA, ANKRD42, PACRG, GLIS3, ROBO1 genes (120). The gene discussed is PACRG; the disease is acrodermatitis enteropathica.