PDCD1 and hypothyroidism: When PD-1 inhibitors are used, MM patients tend to have a) all-grade irAE-GI (colitis and diarrhea) and irAE-skin (rash and pruritis) than NSCLC patients; b) more irAE-GI (diarrhea), irAE-skin, irAE-endocrine (hypothyroidism), and irAE-musculoskeletal (arthralgia) than RCC patients; c) fewer irAE-lung (pneumonitis and dyspnea) compared to NSCLC and RCC patients d) irAE incidence is later than lung cancer patients (5.2 vs. 2.1 months) (21, 34).