Age < 60 years (1.70) (30)Men in PD-1/PD-L1 (0.81) (30–32)Women in CTLA4 (1.5) (31, 33, 34)ECOG ≥ 2 (3.79) (35)Smoking of ≥ 50 pack-years (3.19) or current smoker (HR-2.26) (34–36)Higher body mass index (for ≥ 23 kg/m2, OR=2.62; for ≥ 25kg/m2, OR=1.08) (37–39)Sarcopenia (5.34) (40)Low muscle mass (3.57) (40). The gene discussed is PDCD1; the disease is sarcopenia.