Our results on the functions of MYBL2 and mTOR pathway in malignancy progress now provided the first evidence on the crosstalk between MYBL2 and mTOR pathway in mammals, as well as the role of the MALAT1/MYBL2/mTOR axis in PCa, where MYBL2 promotes the mTOR pathway in PCa cells. The gene discussed is MYBL2; the disease is posterior cortical atrophy.