Therefore, we speculated that ITGA2B and ITGB3 are likely to act in COVID-19-related stroke by participating in integrin signaling and in the response to elevated platelet cytosolic Ca2+, thus regulating platelet activation, ECM-receptor interaction, PI3K-Akt signaling pathway, and hematopoietic cell lineage. The gene discussed is ITGB3; the disease is COVID-19.