ENaC and NCC are important for fine-tuning Na+ reabsorption, K+ secretion and regulating blood pressure as documented by various animal models and diseases such as Liddle’s syndrome and Pseudohypoaldosteronism Type II (increased ENaC and NCC activity may contribute to the observed hypertension) and in Pseudohypoaldosteronism Type I and Gitelman syndrome (reduced ENaC and NCC activity may cause hypotension) (Pradervand et al., 1999; Kleta and Bockenhauer, 2006; Christensen et al., 2010; Furgeson and Linas, 2010). The gene discussed is SLC12A3; the disease is pseudohypoaldosteronism type 2.