SLC12A3 and Hypokalemia: Commonly observed is that aldosterone infusion induces hypokalemia and increases kidney protein abundances of the epithelial Na+ channel (ENaC) and NaCl cotransporter (NCC) in the distal tubule (Kim et al., 1998; Nielsen et al., 2007; Poulsen and Christensen, 2017; Poulsen et al., 2018).