Concerning stroke severity, several studies have shown that circulating Igf1 and Igfbp3 were reduced after stroke and that post-stroke Igf1 and Igfbp3 serum levels were inversely associated with infarct volume (Schwab et al., 1997; Mackay et al., 2003; Denti et al., 2004; Tang et al., 2014). Here, IGFBP3 is linked to Stroke.