PPARG and diabetes mellitus: Besides, PPAR gamma agonist rosiglitazone and sildenafil that acts via a nitric oxide-cyclic guanosine monophosphate pathway, which are known as drugs for the treatment of diabetes and erectile dysfunction respectively, were reported to promote expression of genes associated with browning of WAT (Mohanty et al., 2004; Lefterova et al., 2008; Johann et al., 2018; Di Maio et al., 2021).