However, the associations of other genes used in our model with ICI efficacy have not been reported, although some of them have been found to play critical roles in cancer, such as COL5A2 (Han et al., 2022), FAT2 (Gao et al., 2014), ITPR3 (Wu et al., 2021), PCDH20 (Wang et al., 2016), and UTRN (Zhou et al., 2021). The gene discussed is ITPR3; the disease is cancer.