CD47 and cancer: In their study, the in vitro phagocytosis assays were performed by incubating primary human normal cells and cancer cells with human macrophages with a therapeutic dosage of anti-CD47 antibody, and showed that primary cancer cells were obviously phagocytized, whereas no phagocytosis of normal cells was observed, suggesting that blocking the CD47-SIRPα is not the only rationale for pro-phagocytosis (Chao et al., 2010a).