SIRPA and cancer: Upregulated expression of CD47 on tumor cells increases the interaction with SIRPα on the myeloid cell membrane, leading to a release of the “don’t eat me” signal to evade the phagocytosis of myeloid cells, which is one of the primary mechanisms of cancer and disease formulation (Oldenborg et al., 2000; Jaiswal et al., 2009; Willingham et al., 2012; Hayat et al., 2020; Logtenberg et al., 2020).