The results demonstrated that the mean annual rate of eGFR decline while similar between PA patients treated with adrenalectomy (-0.8 mL/min/1.73m2) and patients with essential hypertension (-0.9 mL/min/1.73m2) were slower than that of PA patients treated with MR antagonists (-1.6 mL/min/1.73m2) (39). This evidence concerns the gene NR3C2 and essential hypertension.