A longitudinal population-based Taiwanese study of 2,367 PA patients without diabetes mellitus at baseline found that targeted therapy with an MR antagonist was associated with an increased risk of incident diabetes mellitus (HR 1.16, P < 0.001) whereas targeted therapy with adrenalectomy was associated with a reduced risk of incident diabetes mellitus (HR 0.61, P < 0.001) (31). This evidence concerns the gene NR3C2 and diabetes mellitus.