From a similar analysis on subjects with the fastest and slowest global cognitive decline (average across the five cognitive domains assessed in the ROSMAP study), there were 21 genes common to both lists (with PRTN3 and ADAMTS2 again ranked highly) (Complete gene lists in Supplementary Table 1) including seven that were common to dementia vs. NCI analysis (PRTN3, GSEC, FAM160A2, ANKRD19P, SLC6A9, SLC4A11, and AQP6). This evidence concerns the gene PRTN3 and Mental deterioration.