While dementia is generally a frequent feature in MAPT mutations (5, 6), among GPSPS, 51.1% presented with PSP-parkinsonism (PSP-P, 20–24%) or PSP-RS (11–18%) motor features, and 41.9% had frontal predominant cognitive symptoms at onset (PSP-F). The gene discussed is MAPT; the disease is supranuclear palsy, progressive, 1.