RNF213 and multiminicore myopathy: Therefore, we designed an angiography-based study using patients from a prospective trial of EDAS surgery to study the locus (c.14429G>A) p.R4810K of the RNF213 and EPCs in patients with MMD, in order to understand the genetic basis and molecular mechanism of these two types of collateral vessels in MMD (native arteriogenesis and therapeutic synangiosis).