Moreover, interactions between eosinophils and neurons through neurotrophic factors including BDNF but also NGF (Raap and Wardlaw, 2008), both produced by eosinophils (Noga et al., 2003), could provide a pathophysiological mechanism to understand the emergence of GI symptoms following immune activation as observed in FD and other DGBI. The gene discussed is BDNF; the disease is Fabry disease.