SCN8A and Intellectual disability: While prior work focused on the role of SCN8A in epileptic encephalopathies, there is evidence in humans and mice that variants in SCN8A are also associated with intellectual disability and neuropsychiatric abnormalities (Trudeau et al., 2006; McKinney et al., 2008; Blanchard et al., 2015; Butler et al., 2017; Wagnon et al., 2017; Liu et al., 2019; Meisler et al., 2021).