Mice of C57BL/6J strain with homozygous loss-of-function of Nav1.6 channels in Purkinje cells exhibit motor deficits and autistic traits such as deficits in social interaction, stereotyped behaviors and anxiety-like behaviors, demonstrating an ASD-like phenotype with strong resemblance to other Purkinje cell-dependent models of ASD (Fatemi et al., 2012; Tsai et al., 2012; Reith et al., 2013; Cupolillo et al., 2016). The gene discussed is SCN8A; the disease is Anxiety.