These clinical features are similar to BFNE caused by KCNQ2 variations and are different from those of autosomal-dominant nocturnal frontal lobe epilepsy (ADNFLE) caused by CHRNA4 variations (Steinlein et al., 1995) and developmental and epileptic encephalopathy 33 (DEE33) caused by EEF1A2 variations (Carvill et al., 2020). This evidence concerns the gene CHRNA4 and undetermined early-onset epileptic encephalopathy.