PPARG and obesity due to melanocortin 4 receptor deficiency: As PPARγ is a key regulator of adipogenesis and adipocyte function, including mitochondrial respiration (222), future studies examining the identity of endothelial-derived PPARγ ligand and elucidating the mechanism by which the activated endothelial cells secrete such ligands may give rise to an alternative drug candidate to combat diseased adiposity in obesity.