TP53 and hepatocellular carcinoma: Studies of human hepatocellular carcinoma have identified etiologies with potential links to mutations in these genes: ARID1A mutations are common in hepatocellular carcinoma related to alcohol intake, G>T mutations at codon 249 of TP53 are common in regions with dietary AFB1 exposure and HBV infection, and CTNNB1 mutations are common in HCV-related hepatocellular carcinomas [38].