Genes mutated in all five lemurs include PI4KA, which is necessary for the propagation of the hepatitis C virus and whose overexpression is associated with poor prognosis in human hepatocellular carcinoma [41] and CNOT1, which, together with IGF2 mRNA-binding proteins, regulates expression of the liver cancer-associated lncRNA HULC [42]. This evidence concerns the gene PI4KA and hepatocellular carcinoma.