As yet, the function of CREB in SySa has not been evaluated, but pathogenic translocations between EWSR1 and CREB or its homologue ATF1 in clear cell sarcoma, another fusion-driven mesenchymal neoplasia, point to a major functional role in mesenchymal tumorigenesis [37, 38]. Here, CREB1 is linked to clear cell sarcoma.