Albeit similar in vitro binding between [225Ac]Ac-PSMA-I&T and [177Lu]Lu-PSMA-I&T allows us to make fair radiobiological comparisons, further in vivo and clinical studies are necessary to investigate the potential differences in biodistribution, and thus tumor uptake, of the two radionuclides, which may impact their effectiveness. Here, FOLH1 is linked to neoplasm.