First, Amp-NETs arose in significantly younger patients (median age: 57 years) compared to Amp-NECs (66 years) and are more frequently associated with hereditary tumor syndromes (15% versus 4%), in particular with NF1, which we observed in 13% of Amp-NETs as a whole and in 21% of SOM-NETs in our series [24, 25]. The gene discussed is NF1; the disease is hereditary neoplastic syndrome.