BRAF and melanoma: Melanomas in sun damaged skin are divided in the current World Health Organization Classification into low cumulative sun damage (CSD) and high CSD, based on the degree of solar elastosis in background dermis, with resulting clinicopathologic and genomic differences.31 Crucial genomic differences include the identification of BRAF V600E alterations in low CSD melanoma and by contrast BRAF non-V600E and NF1 alterations in high CSD melanoma.