Specifically, it is well-established that GAs in CTNNB1/APC and PRKAR1A are associated with deep penetrating nevus and pigmented epithelioid melanocytoma, respectively, both of which have abundant melanin pigment as a histolopathologic feature.32-35 These alterations have also been described in specific subsets of low CSD melanoma.31 The increased percentage of specifically KIT alterations in the HPMel group is likely secondary to enrichment for anogenital mucosal primary site cases (8/18 cases), which often contain increased pigmentation.36,37. This evidence concerns the gene CTNNB1 and melanoma.