While spindlin-2B (human homologue of ENSOARG00020023439), is involved in regulation of cell cycle progression [35] and H3K4me3-binding activity [36], TPGS2 codes for a protein component of neuronal polyglutamylase complex [37], whereas SCNN1B is responsible for sodium channel activity and mutation of the gene leads to autosomal disorders like Liddle syndrome [38]. The gene discussed is SCNN1B; the disease is Liddle syndrome.