CXCL12 and diabetes mellitus: Experimental diabetes induces a change in the transcriptomic profile of BM endothelial cells involving Cxcl12 and genes of the Egfr signaling, which regulate HSPC retention and quiescence.46 BM adipocytes are an important source of Cxcl12 that retain HSPCs within the BM niche, preventing them from being mobilized into PB.37 Cxcl12 is produced by several stromal cell types within the BM niche and signals in HSPCs via its receptor CXCR4.