To pinpoint specific changes due to the KO of core-clock genes, we additionally gathered publicly available time-course RNA-seq datasets for human CRC cell lines (SW480: derived from the primary tumour, SW620: derived from a metastasis site, from the same patient), HL cell lines (HDMYZ: stage III, L1236: stage IV), murine WT and Arntl KO, murine WT and Nr1d1/2 KO, murine SCN tissue, murine WT and Cry1/2 KO, and murine WT and Per1/2 KO, resulting in a total of 222 samples (Fig. 1a). The gene discussed is CLOCK; the disease is neoplasm.