Finally, we observed KO-specific altered expression and rhythmicity pattern of transcripts associated with cancer hallmarks related genes such as in Fibroblast Growth Factor Receptor 2 (FGFR2), which promotes tumour progression seen in HCT116_ARNTLKO, Caspase 8 (CASP8) which regulates extrinsic apoptotic pathway seen in HCT116_NR1D1KO, and HRas proto-oncogene, GTPase (HRAS) involved in cell proliferation, growth and apoptosis detected in HCT116_PER2KO. The gene discussed is CASP8; the disease is cancer.