INSR and neoplasm: In addition, alterations in the expression of several SFs can impact the splicing of their target genes, for e.g., the differential expression of the splicing factor Serine and Arginine Rich Splicing Factor 6 (SRSF6) affects the splicing of several oncogenes including the Insulin Receptor (INSR), MAPK Interacting Serine/Threonine Kinase 2 (MKNK2) and Discs Large MAGUK Scaffold Protein 1 (DLG1) leading to the production of oncogenic isoforms, or to the reduction of the tumour-suppressing isoforms of those genes16.