Also, aberrant AS in other members of the SR splicing factor and SR-like families, including SRSF4 and Transformer 2 Beta Homolog (TRA2β) have been shown to regulate cancer proliferation and metastasis by affecting the splicing of genes involved in epithelial-mesenchymal transition (EMT, e.g., CD44) in breast cancer17. This evidence concerns the gene CD44 and cancer.