From the IHC of initial surgical specimens with our original microarray data (KOV, GSE39204/55512, n = 28), the ratio of cases with TLS was significantly higher in those with high CXCL13 gene expression than in those with low CXCL13 gene expression in tumor specimens (P = 0.046; Figure 2B). This evidence concerns the gene CXCL13 and neoplasm.