Under inflammatory conditions, neutrophils release a variety of cytokines, one of which is CXCL12, which was significantly elevated in tumor supernatant from B16.BL6-bearing mice that had been treated with anti–CTLA-4 and 7HP349 (Figure 3F), for which chemokine receptor CXCR4 is expressed on CD8+ Teffs (Supplemental Figure 8). This evidence concerns the gene CD8A and neoplasm.