CD8A and neoplasm: The observed strong correlation between neutrophils and CD8+ Teffs and its corresponding negative association with tumor burden in mice undergoing 7HP349 treatment (Figure 4E and Supplemental Figure 11A) prompted us to determine the extent to which the perceived cooperation between CD8+ Teffs and neutrophils is critical for the CD8+ T cell–dependent antitumor response (Figure 4D).