When examining the factors that could contribute to CD8+ Teff tumor recruitment, we found that CD8+ Teffs expressed the chemokine receptors CXCR3 and CXCR4, while the TME produced abundant CXCL9 and CXCL12, which are the key chemokines known to bind CXCR3 and CXCR4, respectively. The gene discussed is CXCR4; the disease is neoplasm.